abstract：:The manifestation of pain in any individual patient may result from a variety of underlying mechanisms that also may vary from one disease state to another. Global measures of pain intensity and relief are inadequate for characterizing specific pain qualities or identifying the unique effects of pain treatments on dif...

journal_title：Current medical research and opinion

authors： Jensen MP

更新日期：2004-01-01 00:00:00

abstract：PURPOSE:Tamoxifen, used in breast cancer treatment, may induce hepatic steatosis. It has been suggested that leptin, which has a relationship with body fat stores, may be involved in the pathogenesis of hepatic steatosis. In this study, we compared serum leptin levels in tamoxifen-treated patients with and without hepa...

journal_title：Current medical research and opinion

authors： Günel N,Coşkun U,Toruner FB,Sancak B,Yilmaz E,Cengiz O,Elbeg S,Uner A,Ozkan S

更新日期：2003-01-01 00:00:00

abstract：:Historically, the approach to atherogenesis research has been focused on factors that primarily include vessel wall histology, blood and vessel wall biochemistry, clotting factors and platelets. This approach can be referred to as the 'biochemical' approach. We now recognize that atherosclerosis is an ongoing sterile ...

journal_title：Current medical research and opinion

authors： Kensey KR

更新日期：2003-01-01 00:00:00

abstract：:The results of recent clinical trials with rivastigmine show that in the approved indication of mild to moderate Alzheimer's disease (AD), the drug is effective in the long term. Rivastigmine produces a significant delay in the decline of the three components of AD that have been identified by European guidelines as e...

journal_title：Current medical research and opinion

authors： Gabelli C

更新日期：2003-01-01 00:00:00

abstract：:The efficacy of trimetazidine, an anti-ischaemic agent, has been largely assessed and presented in the international literature through its metabolic effects, selective and specific fatty acid oxidation inhibition and lack of haemodynamic effects in stable angina pectoris. As such, trimetazidine has opened up a new cl...

journal_title：Current medical research and opinion

authors： Marzilli M

更新日期：2003-01-01 00:00:00

abstract：:Stress urinary incontinence (SUI) is the involuntary loss of urine associated with physical activities such as running, jumping, or lifting, or with sneezing and coughing. For many patients it can be a very bothersome symptom, causing social isolation, loss of self-esteem, and increased expenses. Although there is cur...

journal_title：Current medical research and opinion

authors： Viktrup L,Bump RC

更新日期：2003-01-01 00:00:00

abstract：:For over a century, there has been considerable interest in the management of regional lymph node metastasis in patients with primary breast cancer. Since the advent of sentinel lymph node biopsies, there has been renewed interest in the management of patients with metastasis to the internal mammary nodes. The appropr...

journal_title：Current medical research and opinion

authors： Jatoi I

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:To investigate the use of traditional non-steroidal anti-inflammatory drugs (tNSAIDs) in the management of osteoarthritis (OA) in primary care in Spain and to quantify patient and physician satisfaction with tNSAID therapy. METHODS:A 6-month retrospective, observational study conducted in 29 Spanish primary-...

journal_title：Current medical research and opinion

authors： Arboleya LR,de la Figuera E,Soledad García M,Aragón B,VICOXX Study Group.

更新日期：2003-01-01 00:00:00

abstract：:Acetyl-L-carnitine (ALC) is a compound acting as an intracellular carrier of acetyl groups across inner mitochondrial membranes. It also appears to have neuroprotective properties and it has recently been shown to reduce attention deficits in patients with Alzheimer's disease (AD) after long-term treatment. We perform...

journal_title：Current medical research and opinion

authors： Bianchetti A,Rozzini R,Trabucchi M

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Persisting pain is demoralising and debilitating for patients and their carers. Most patients with chronic pain do not need the services of a specialised pain clinic and are appropriately managed by their general practitioner (GP). METHOD:Interviewers approached 569 GPs to assess their satisfaction with the...

journal_title：Current medical research and opinion

authors： Stannard C,Johnson M

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:Poor quality has been reported for some generics and other copies of original products. We performed a pilot study to compare the disintegration/dissolution profiles of FOSAMAX (alendronate) 70 mg tablets with those of copies of FOSAMAX that were manufactured outside the United States. RESEARCH DESIGN AND ME...

journal_title：Current medical research and opinion

authors： Epstein S,Cryer B,Ragi S,Zanchetta JR,Walliser J,Chow J,Johnson MA,Leyes AE

更新日期：2003-01-01 00:00:00

abstract：:Recombinant human erythropoietin (epoetin) is a highly active molecule and as such is used at very low therapeutic concentrations that require stabilisation. Commercially available epoetins differ in the stabilisers used in their formulations, which result in variations between epoetin preparations in storage and hand...

journal_title：Current medical research and opinion

authors： Haselbeck A

更新日期：2003-01-01 00:00:00

abstract：:This study evaluated the prognostic significance of several risk factors on the outcome of coronary heart disease (CHD) in 639 cardiovascular disease-free subjects with heterozygous familial hypercholesterolaemia (FH). During the 15-year follow-up, 53 (18%) men and 34 (9.8%) women had a CHD event (men vs women, p < 0....

journal_title：Current medical research and opinion

authors： Panagiotakos DB,Pitsavos C,Skoumas J,Chrysohoou C,Toutouza M,Stefanadis CI,Toutouzas PK

更新日期：2003-01-01 00:00:00

abstract：:Breast cancer was the focus of several presentations during the 27th European Society of Medical Oncology (ESMO) Congress held in Nice. Fulvestrant seems to be equally effective to tamoxifen as a first-line therapy in hormone-sensitive advanced breast cancer in postmenopausal women. However, it may be more effective t...

journal_title：Current medical research and opinion

authors： Mokbel K

更新日期：2003-01-01 00:00:00

abstract：:All the components of the kallikrein-kinin system are located in the vascular smooth muscle as well as in the heart. In recent years, numerous observations obtained from clinical and experimental models of diabetes, hypertension, cardiac failure, ischaemia, myocardial infarction and left ventricular hypertrophy, have ...

journal_title：Current medical research and opinion

authors： Sharma JN,Sharma J

更新日期：2002-01-01 00:00:00

abstract：:Diabetes mellitus ia very common disease with a high cardiovascular morbidity and mortality. This articles reviews the types of lipid disorders that can accompany diabetes mellitus and the evidence that treatment of dyslipidaemia improves primary and secondary endpoints, i.e. lipid levels, cardiovascular events, and m...

journal_title：Current medical research and opinion

authors： Goguen JM,Leiter LA

更新日期：2002-01-01 00:00:00

abstract：:Neuroprotective agents inhibit reactions in the brain ischaemic injury cascade which lead to neuronal death. Gamma-aminobutyric acid (GABA) is a naturally occurring inhibitory neurotransmitter that increases chloride influx into the neuron and counteracts the toxic effects of glutamate. Clomethiazole is a GABA(A) agon...

journal_title：Current medical research and opinion

authors： Vaishnav A,Lutsep HL

更新日期：2002-01-01 00:00:00

abstract：:Effective management of influenza depends on early recognition of influenza in the community and on rapid diagnosis. Early recognition is achieved by integrated clinical and laboratory based surveillance programmes in representative populations. The recent introduction of 'near patient tests' for influenza provide inc...

journal_title：Current medical research and opinion

authors： Fleming D,Wood M

更新日期：2002-01-01 00:00:00

abstract：GOALS OF THE WORK:This open compassionate-use prospective registration study evaluated the tolerability, ease of use and applied doses of transdermal (TTS) fentanyl in adult patients with cancer-related pain requiring strong opioid analgesia. Elderly patients were particularly focussed on. PATIENTS AND METHODS:Previou...

journal_title：Current medical research and opinion

authors： Menten J,Desmedt M,Lossignol D,Mullie A

更新日期：2002-01-01 00:00:00

abstract：:During the past decades several epidemiological studies have provided a 'portrait' of the potential candidate for cardiovascular disease, introducing many emerging life-style risk factors such as obesity, unhealthy diet, exposure to passive smoking, lack of exercise, psychosocial stress, and depression, as well as ele...

journal_title：Current medical research and opinion

authors： Pitsavos CE,Toutouzas PK

更新日期：2002-01-01 00:00:00

abstract：:Studies in several populations have indicated that genetic variation at the apolipoprotein E (apoE) structural locus influences the risk of coronary artery disease (CAD) and myocardial infarction (MI). This study aimed at investigating whether apoE polymorphism has an allelic and/or genotypic impact on the risk of MI ...

journal_title：Current medical research and opinion

authors： Kolovou G,Yiannakouris N,Hatzivassiliou M,Malakos J,Daskalova D,Hatzigeorgiou G,Cariolou MA,Cokkinos DV

更新日期：2002-01-01 00:00:00

abstract：:As more and more novel antipsychotic agents are introduced, the need for practical guidelines on switching these medications is becoming increasingly important. Indications for a switch include situations where the patient or his family/caregiver requests a change in medication, where the patient cannot tolerate curre...

journal_title：Current medical research and opinion

authors： Burns T,Chabannes JP,Demyttenaere K

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:Hyperuricaemia is associated with indapamide administration. In contrast, micronised fenofibrate can significantly decrease serum uric acid levels. However, there are no data on the effect of combination therapy of indapamide with micronised fenofibrate on uric acid metabolism. METHODS:We studied 20 non-diab...

journal_title：Current medical research and opinion

authors： Achimastos A,Liberopoulos E,Nikas S,Bairaktari E,Miltiadous G,Tsimihodimos V,Elisaf M

更新日期：2002-01-01 00:00:00

abstract：:Doxofylline (7-(1,3-dioxalan-2-ylmethyl) theophylline) is a novel xanthine bronchodilator which differs from theophylline in that it contains a dioxalane group in position 7. Similarly to theophylline, its mechanism of action is related to the inhibition of phosphodiesterase activities, but in contrast it appears to h...

journal_title：Current medical research and opinion

authors： Dini FL,Cogo R

更新日期：2001-01-01 00:00:00

abstract：:Migraine is a very common disorder, affecting about 11% of adult populations in Western countries. Prevalence is highest during the peak productive years--between the ages of 25 and 55. The prevalence is higher in females than males at all post-pubertal ages, but the sex ratio varies with age. In the United States, mi...

journal_title：Current medical research and opinion

authors： Lipton RB,Stewart WF,Scher AI

更新日期：2001-01-01 00:00:00

abstract：:The potential advantages of eletriptan lie firstly in its lipophilicity reflected as an increased rate of absorption and Tmax compared to sumatriptan. This is manifested in a modest advantage over sumatriptan in terms of speed of onset, 2 h headache response and 2 h pain free. However, eletriptan has not yet been show...

journal_title：Current medical research and opinion

authors： Giffin N

更新日期：2001-01-01 00:00:00

abstract：:Poor nutritional status may impair well being indirectly as a consequence of increased morbidity and decline in functional status. The aim of this study was to examine the independent effect of body mass index on the well being of older people. Thirty one hospital-based patients over 65 years of age were studied. Well...

journal_title：Current medical research and opinion

authors： Balcombe NR,Ferry PG,Saweirs WM

更新日期：2001-01-01 00:00:00

abstract：:Control of hypertension is hindered by the incidence of adverse events associated with therapy, which can result in low patient compliance. Specific angiotensin II receptor subtype AT1 blockers offer an alternative to the angiotensin converting enzyme inhibitors in the treatment of hypertension, as the incidence of si...

journal_title：Current medical research and opinion

authors： Levine B

更新日期：2001-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disorder of the elderly, characterised by widespread loss of central cholinergic function. The only symptomatic treatment proven effective to date is the use of cholinesterase (ChE) inhibitors to augment surviving cholinergic activity. ChE inhibitors act on t...

journal_title：Current medical research and opinion

authors： Greig NH,Utsuki T,Yu Q,Zhu X,Holloway HW,Perry T,Lee B,Ingram DK,Lahiri DK

更新日期：2001-01-01 00:00:00

abstract：:The most common side-effect of statins, mainly during dose titration, is liver toxicity, In these cases, sufficient control of low density lipoprotein cholesterol (LDL-C) in patients with heterozygous familial hypercholesterolaemia (HFH) becomes problematical. In patients with intolerance to resins as well, especially...

journal_title：Current medical research and opinion

authors： Athyros VG,Papageorgiou AA,Demitriadis DS,Kontopoulos AG

更新日期：2001-01-01 00:00:00

abstract：:Data from phase III clinical trials suggest that high dose chemotherapy (HDC) is currently not indicated for any stage of breast cancer. Therefore HDC should only be considered within the context of clinical trials. Furthermore, there is no significant evidence to support the routine use of taxanes in women with metas...

journal_title：Current medical research and opinion

authors： Mokbel K,Elkak A

更新日期：2001-01-01 00:00:00

abstract：:Hypertension is another predictor of erectile dysfunction (ED). This is further evidence supporting a link between the pathogenesis of atherosclerotic disease and ED. In one study (TOMHS) involving hypertensive patients, the incidence of ED was 14.4%. The drugs used to treat hypertension may cause ED. However, there i...

journal_title：Current medical research and opinion

authors： Mikhailidis DP,Khan MA,Milionis HJ,Morgan RJ

更新日期：2000-01-01 00:00:00

abstract：:Angiotensin converting enzyme (ACE) inhibitors have been avoided as an initial therapeutic option in the treatment of hypertension in African-Americans. A major reason for this has been the widespread perception of clinicians that these agents have poor blood pressure (BP) lowering efficacy in this population. Remarka...

journal_title：Current medical research and opinion

authors： Flack JM,Mensah GA,Ferrario CM

更新日期：2000-01-01 00:00:00

abstract：UNLABELLED:The occurrence of intestinal bacterial overgrowth in patients with Crohn's Disease (CD) has been described and antimicrobial treatment has been shown to be effective in reversing this condition. However, the mechanisms underlying the efficacy of antimicrobial therapy are still only partially known. The aim o...

journal_title：Current medical research and opinion

authors： Biancone L,Vernia P,Agostini D,Ferrieri A,Pallone F

更新日期：2000-01-01 00:00:00

abstract：:Amlodipine, a dihydropyrimidine calcium antagonist, is effective in the treatment of patients with mild to moderate hypertension at doses of 5-10 mg daily. The aim of the study reported here was to determine whether an early increase in dosage of amlodipine provided an advantage in terms of antihypertensive effect. Th...

journal_title：Current medical research and opinion

authors： Hayduk K,Adamczak M,Nowitzki G

更新日期：1999-01-01 00:00:00

abstract：:Zolmitriptan is a 5-HT1B/1D receptor agonist for the acute treatment of migraine. This study examined the efficacy of a second dose of zolmitriptan for the treatment of persistent or recurrent headache. Part 1 was a randomised, placebo-controlled, double-blind evaluation of 2.5 mg and 5 mg zolmitriptan for the treatme...

journal_title：Current medical research and opinion

authors： Mauskop A,Farkkila M,Hering-Hanit R,Rapoport A,Warner J

更新日期：1999-01-01 00:00:00

abstract：:Quetiapine fumarate is a novel dibenzothiazepine antipsychotic developed by Zeneca. It is marketed under the trade name 'Seroquel'. Quetiapine is well tolerated and clinically effective in the treatment of schizophrenia. The initial hope of investigators was that quetiapine would have antipsychotic potential and that ...

journal_title：Current medical research and opinion

authors： Green B

更新日期：1999-01-01 00:00:00

abstract：:Elevated serum cholesterol level is a key risk factor for cardiovascular morbidity and mortality. Cerivastatin is a highly effective lipid-lowering agent currently licensed at doses of 0.1, 0.2, 0.3 and 0.4 mg. This was a multicentre, randomised, double-blind, parallel-group study comparing the efficacy and safety of ...

journal_title：Current medical research and opinion

authors： Ose L,Luurila O,Eriksson J,Olsson A,Lithell H,Widgren B

更新日期：1999-01-01 00:00:00

abstract：:Olanzapine (2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine) is a novel antipsychotic agent of the theinobenzodiazepine class developed by Eli Lilly & Co. It has a pleotrophic pharmacology and affects the dopaminergic, serotonergic, muscarinic and adrenergic systems. The therapeutic advantage...

journal_title：Current medical research and opinion

authors： Green B

更新日期：1999-01-01 00:00:00

abstract：:Twenty-nine patients undergoing cholecystectomy because of chronic calculous cholecystitis were randomised to receive phenylbutazone 10 mg/kg intramuscularly or a control injection (vehicle-containing local anaesthetic) immediately after completion of surgery. Fibrinogen and plasminogen concentrations in plasma, plasm...

journal_title：Current medical research and opinion

authors： Szczepański M,Kubiak J,Lembas L

更新日期：1998-01-01 00:00:00